The aim of this study was to investigate a mediator role of cynicism in the relationship between loneliness and resilience. Participants were 302 teacher candidates [177 (58.6%) female, 125 (41.4%) male, Mage = 23.14 years, SD = 2.38] who completed questionnaires package the UCLA Loneliness Scale, the Resilience Scale and the Hunter Cynicism Scale. The data were analyzed using structural equation modeling. A bootstrapping analysis was conducted in order to determine any indirect effects. The results showed that loneliness predicted cynicism positively and resilience negatively, and that cynicism predicted resilience negatively. It was further found that the structural equation model that proposed that loneliness had a direct and an indirect effect through cynicism on resilience was confirmed. The results of the study were discussed in the light of relevant literature, and suggestions for future studies were made.