This study aims to examine the effect of gender on student burnout using the meta-analysis method. Within the scope of the research, it was aimed to reveal the size and direction of the gender difference in student burnout. Besides, it was aimed to determine the variables that had a mediating effect on the relationship between gender and student burnout. By the selection criteria of the research, a total of 43 papers have been included in the meta-analysis. The sample of the study consists of 22.954 students, 11.986 girls, and 10.968 boys. “Hedges g” value was calculated to determine the effect size. As a result of the process of combining the individual effect sizes of the studies in the random-effects model, an effect size (g = -.069) was obtained at a weak level and in favor of male students. Besides, it was concluded that the effect sizes differ according to the continent where the study was conducted and the faculty. In other words, the research results show that these variables have a mediating effect on the relationship between gender and student burnout.